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Exosome-based supply methods for tumor remedy: an replace on modification, loading, and medical software | Journal of Nanobiotechnology


  • Siegel RL, Miller KD, Fuchs HE, Jemal A. Most cancers statistics, 2022. CA Most cancers J Clin. 2022;72:7–33.

    Article 
    PubMed 

    Google Scholar
     

  • Akbari A, Nazari-Khanamiri F, Ahmadi M, Shoaran M, Rezaie J. Engineered exosomes for tumor-targeted drug supply: a deal with genetic and chemical functionalization. Pharmaceutics. 2022;15:78.

    Article 

    Google Scholar
     

  • Ngoune R, Peters A, von Elverfeldt D, Winkler Ok, Pütz G. Accumulating nanoparticles by EPR: A route of no return. J Management Launch. 2016;238:58–70.

    Article 
    PubMed 

    Google Scholar
     

  • Li H, Wu Z, Zhang J, Solar X, Duan F, Yao J, Solar M, Zhang J, Nie L. Instantaneous ultrasound-evoked exact nanobubble explosion and deep photodynamic remedy for tumors guided by molecular imaging. ACS Appl Mater Interfaces. 2021;13:21097–107.

    Article 
    PubMed 

    Google Scholar
     

  • Chen R, Huang S, Lin T, Ma H, Shan W, Duan F, Lv J, Zhang J, Ren L, Nie L. Photoacoustic molecular imaging-escorted adipose photodynamic-browning synergy for preventing weight problems with virus-like complexes. Nat Nanotechnol. 2021;16:455–65.

    Article 
    PubMed 

    Google Scholar
     

  • Joseph TM, Kar Mahapatra D, Esmaeili A, Piszczyk Ł, Hasanin MS, Kattali M, Haponiuk J, Thomas S. Nanoparticles: taking a novel place in medication. Nanomaterials (Basel). 2023;13:78.

    Article 

    Google Scholar
     

  • Kim H, Kim EH, Kwak G, Chi SG, Kim SH, Yang Y. Exosomes: cell-derived nanoplatforms for the supply of most cancers therapeutics. Int J Mol Sci. 2020;22:67.

    Article 

    Google Scholar
     

  • Arrighetti N, Corbo C, Evangelopoulos M, Pastò A, Zuco V, Tasciotti E. Exosome-like nanovectors for drug supply in most cancers. Curr Med Chem. 2019;26:6132–48.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Pathan M, Fonseka P, Chitti SV, Kang T, Sanwlani R, Van Deun J, Hendrix A, Mathivanan S. Vesiclepedia 2019: a compendium of RNA, proteins, lipids and metabolites in extracellular vesicles. Nucleic Acids Res. 2019;47:D516-d519.

    Article 
    PubMed 

    Google Scholar
     

  • Wiklander OPB, Brennan M, Lötvall J, Breakefield XO, El Andaloussi S. Advances in therapeutic purposes of extracellular vesicles. Sci Transl Med. 2019;11:54.

    Article 

    Google Scholar
     

  • Yu D, Li Y, Wang M, Gu J, Xu W, Cai H, Fang X, Zhang X. Exosomes as a brand new frontier of most cancers liquid biopsy. Mol Most cancers. 2022;21:56.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kalluri R, LeBleu VS. The biology, perform, and biomedical purposes of exosomes. Science. 2020;367:67.

    Article 

    Google Scholar
     

  • Ginini L, Billan S, Fridman E, Gil Z. Perception into extracellular vesicle-cell communication: from cell recognition to intracellular destiny. Cells. 2022;11:78.

    Article 

    Google Scholar
     

  • Lin S, Yu Z, Chen D, Wang Z, Miao J, Li Q, Zhang D, Track J, Cui D. Progress in microfluidics-based exosome separation and detection applied sciences for diagnostic purposes. Small. 2020;16: e1903916.

    Article 
    PubMed 

    Google Scholar
     

  • Colombo M, Raposo G, Théry C. Biogenesis, secretion, and intercellular interactions of exosomes and different extracellular vesicles. Annu Rev Cell Dev Biol. 2014;30:255–89.

    Article 
    PubMed 

    Google Scholar
     

  • Buratta S, Tancini B, Sagini Ok, Delo F, Chiaradia E, Urbanelli L, Emiliani C. Lysosomal Exocytosis, Exosome Launch and Secretory Autophagy: The Autophagic- and Endo-Lysosomal Techniques Go Extracellular. Int J Mol Sci. 2020;21:78.

    Article 

    Google Scholar
     

  • Chen J, Li P, Zhang T, Xu Z, Huang X, Wang R, Du L. Assessment on methods and applied sciences for exosome isolation and purification. Entrance Bioeng Biotechnol. 2021;9: 811971.

    Article 
    PubMed 

    Google Scholar
     

  • Dixson AC, Dawson TR, Di Vizio D, Weaver AM. Context-specific regulation of extracellular vesicle biogenesis and cargo choice. Nat Rev Mol Cell Biol. 2023;24:454.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Katzmann DJ, Stefan CJ, Babst M, Emr SD. Vps27 recruits ESCRT equipment to endosomes throughout MVB sorting. J Cell Biol. 2003;162:413–23.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Nickerson DP, Russell MR, Odorizzi G. A concentric circle mannequin of multivesicular physique cargo sorting. EMBO Rep. 2007;8:644–50.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Hurley JH, Emr SD. The ESCRT complexes: construction and mechanism of a membrane-trafficking community. Annu Rev Biophys Biomol Struct. 2006;35:277–98.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Tschuschke M, Kocherova I, Bryja A, Mozdziak P, Angelova Volponi A, Janowicz Ok, Sibiak R, Piotrowska-Kempisty H, Iżycki D, Bukowska D, et al. Inclusion biogenesis, strategies of isolation and medical software of human mobile exosomes. J Clin Med. 2020;9:34.

    Article 

    Google Scholar
     

  • Trajkovic Ok, Hsu C, Chiantia S, Rajendran L, Wenzel D, Wieland F, Schwille P, Brügger B, Simons M. Ceramide triggers budding of exosome vesicles into multivesicular endosomes. Science. 2008;319:1244–7.

    Article 
    PubMed 

    Google Scholar
     

  • Wortzel I, Dror S, Kenific CM, Lyden D. Exosome-mediated metastasis: communication from a distance. Dev Cell. 2019;49:347–60.

    Article 
    PubMed 

    Google Scholar
     

  • Lässer C, Shelke GV, Yeri A, Kim DK, Crescitelli R, Raimondo S, Sjöstrand M, Gho YS, Van Keuren JK, Lötvall J. Two distinct extracellular RNA signatures launched by a single cell sort recognized by microarray and next-generation sequencing. RNA Biol. 2017;14:58–72.

    Article 
    PubMed 

    Google Scholar
     

  • Rahbarghazi R, Jabbari N, Sani NA, Asghari R, Salimi L, Kalashani SA, Feghhi M, Etemadi T, Akbariazar E, Mahmoudi M, Rezaie J. Tumor-derived extracellular vesicles: dependable instruments for Most cancers prognosis and medical purposes. Cell Commun Sign. 2019;17:73.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Konečná B, Tóthová Ľ, Repiská G. Exosomes-Related DNA-New Marker in Being pregnant Problems? Int J Mol Sci. 2019;20:2890.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • O’Brien Ok, Breyne Ok, Ughetto S, Laurent LC, Breakefield XO. RNA supply by extracellular vesicles in mammalian cells and its purposes. Nat Rev Mol Cell Biol. 2020;21:585–606.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Terstappen GC, Meyer AH, Bell RD, Zhang W. Methods for delivering therapeutics throughout the blood-brain barrier. Nat Rev Drug Discov. 2021;20:362–83.

    Article 
    PubMed 

    Google Scholar
     

  • Miceli V, Bulati M, Iannolo G, Zito G, Gallo A, Conaldi PG. Therapeutic properties of mesenchymal stromal/stem cells: the necessity of cell priming for cell-free therapies in regenerative medication. Int J Mol Sci. 2021;22:234.

    Article 

    Google Scholar
     

  • Mendt M, Rezvani Ok, Shpall E. Mesenchymal stem cell-derived exosomes for medical use. Bone Marrow Transplant. 2019;54:789–92.

    Article 
    PubMed 

    Google Scholar
     

  • Xunian Z, Kalluri R. Biology and therapeutic potential of mesenchymal stem cell-derived exosomes. Most cancers Sci. 2020;111:3100–10.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Pomatto M, Gai C, Negro F, Cedrino M, Grange C, Ceccotti E, Togliatto G, Collino F, Tapparo M, Figliolini F, et al. Differential therapeutic impact of extracellular vesicles derived by bone marrow and adipose mesenchymal stem cells on wound therapeutic of diabetic ulcers and correlation to their cargoes. Int J Mol Sci. 2021;22:23.

    Article 

    Google Scholar
     

  • Lou G, Chen L, Xia C, Wang W, Qi J, Li A, Zhao L, Chen Z, Zheng M, Liu Y. MiR-199a-modified exosomes from adipose tissue-derived mesenchymal stem cells enhance hepatocellular carcinoma chemosensitivity by mTOR pathway. J Exp Clin Most cancers Res. 2020;39:4.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Li T, Zhou X, Wang J, Liu Z, Han S, Wan L, Solar X, Chen H. Adipose-derived mesenchymal stem cells and extracellular vesicles confer antitumor exercise in preclinical therapy of breast most cancers. Pharmacol Res. 2020;157:104843.

    Article 
    PubMed 

    Google Scholar
     

  • Wang S, Solar J, Dastgheyb RM, Li Z. Tumor-derived extracellular vesicles modulate innate immune responses to have an effect on tumor development. Entrance Immunol. 2022;13:1045624.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Christofides A, Strauss L, Yeo A, Cao C, Charest A, Boussiotis VA. The advanced position of tumor-infiltrating macrophages. Nat Immunol. 2022;23:1148–56.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wu Ok, Lin Ok, Li X, Yuan X, Xu P, Ni P, Xu D. Redefining tumor-associated macrophage subpopulations and features within the tumor microenvironment. Entrance Immunol. 2020;11:1731.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Nie W, Wu G, Zhang J, Huang LL, Ding J, Jiang A, Zhang Y, Liu Y, Li J, Pu Ok, Xie HY. Responsive exosome nano-bioconjugates for synergistic most cancers remedy. Angew Chem Int Ed Engl. 2020;59:2018–22.

    Article 
    PubMed 

    Google Scholar
     

  • Marar C, Starich B, Wirtz D. Extracellular vesicles in immunomodulation and tumor development. Nat Immunol. 2021;22:560–70.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Lindenbergh MFS, Stoorvogel W. Antigen presentation by extracellular vesicles from skilled antigen-presenting cells. Annu Rev Immunol. 2018;36:435–59.

    Article 
    PubMed 

    Google Scholar
     

  • Xu Z, Zeng S, Gong Z, Yan Y. Exosome-based immunotherapy: a promising strategy for most cancers therapy. Mol Most cancers. 2020;19:160.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Lu Z, Zuo B, Jing R, Gao X, Rao Q, Liu Z, Qi H, Guo H, Yin H. Dendritic cell-derived exosomes elicit tumor regression in autochthonous hepatocellular carcinoma mouse fashions. J Hepatol. 2017;67:739–48.

    Article 
    PubMed 

    Google Scholar
     

  • Vergani E, Daveri E, Vallacchi V, Bergamaschi L, Lalli L, Castelli C, Rodolfo M, Rivoltini L, Huber V. Extracellular vesicles in anti-tumor immunity. Semin Most cancers Biol. 2022;86:64–79.

    Article 
    PubMed 

    Google Scholar
     

  • Wolfers J, Lozier A, Raposo G, Regnault A, Théry C, Masurier C, Flament C, Pouzieux S, Faure F, Tursz T, et al. Tumor-derived exosomes are a supply of shared tumor rejection antigens for CTL cross-priming. Nat Med. 2001;7:297–303.

    Article 
    PubMed 

    Google Scholar
     

  • Rana S, Yue S, Stadel D, Zöller M. Towards tailor-made exosomes: the exosomal tetraspanin net contributes to focus on cell choice. Int J Biochem Cell Biol. 2012;44:1574–84.

    Article 
    PubMed 

    Google Scholar
     

  • Fang JH, Zhang ZJ, Shang LR, Luo YW, Lin YF, Yuan Y, Zhuang SM. Hepatoma cell-secreted exosomal microRNA-103 will increase vascular permeability and promotes metastasis by focusing on junction proteins. Hepatology. 2018;68:1459–75.

    Article 
    PubMed 

    Google Scholar
     

  • Dai S, Wei D, Wu Z, Zhou X, Wei X, Huang H, Li G. Part I medical trial of autologous ascites-derived exosomes mixed with GM-CSF for colorectal most cancers. Mol Ther. 2008;16:782–90.

    Article 
    PubMed 

    Google Scholar
     

  • Liu C, Su C. Design methods and software progress of therapeutic exosomes. Theranostics. 2019;9:1015–28.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Mu J, Zhuang X, Wang Q, Jiang H, Deng ZB, Wang B, Zhang L, Kakar S, Jun Y, Miller D, Zhang HG. Interspecies communication between plant and mouse intestine host cells by edible plant derived exosome-like nanoparticles. Mol Nutr Meals Res. 2014;58:1561–73.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Cai Q, Qiao L, Wang M, He B, Lin FM, Palmquist J, Huang SD, Jin H. Vegetation ship small RNAs in extracellular vesicles to fungal pathogen to silence virulence genes. Science. 2018;360:1126–9.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Tinnirello V, Rabienezhad Ganji N, De Marcos LC, Alessandro R, Raimondo S. Exploiting the chance to make use of plant-derived nanoparticles as supply automobiles. Vegetation (Basel). 2023;12:1207.

    Article 
    PubMed 

    Google Scholar
     

  • Dong F, Dong X, Zhou L, Xiao H, Ho PY, Wong MS, Wang Y. Doxorubicin-loaded biodegradable self-assembly zein nanoparticle and its anti-cancer impact: Preparation, in vitro analysis, and mobile uptake. Colloids Surf B Biointerfaces. 2016;140:324–31.

    Article 
    PubMed 

    Google Scholar
     

  • Del Pozo-Acebo L. Therapeutic potential of broccoli-derived extracellular vesicles as nanocarriers of exogenous miRNAs. Pharmacol Res. 2022;185: 106472.

    Article 
    PubMed 

    Google Scholar
     

  • Zhuang X, Deng ZB, Mu J, Zhang L, Yan J, Miller D, Feng W, McClain CJ, Zhang HG. Ginger-derived nanoparticles defend towards alcohol-induced liver injury. J Extracell Vesicles. 2015;4:28713.

    Article 
    PubMed 

    Google Scholar
     

  • Rahimi Ghiasi M, Rahimi E, Amirkhani Z, Salehi R. Leucine-rich Repeat-containing G-protein coupled receptor 5 gene overexpression of the rat small intestinal progenitor cells in response to orally administered grape exosome-like nanovesicles. Adv Biomed Res. 2018;7:125.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Liangsupree T, Multia E, Riekkola ML. Trendy isolation and separation strategies for extracellular vesicles. J Chromatogr A. 2021;1636: 461773.

    Article 
    PubMed 

    Google Scholar
     

  • Wang C, Xu M, Fan Q, Li C, Zhou X. Therapeutic potential of exosome-based personalised supply platform in persistent inflammatory ailments. Asian J Pharm Sci. 2023;18:100772.

    Article 
    PubMed 

    Google Scholar
     

  • Franco C, Ghirardello A, Bertazza L, Gasparotto M, Zanatta E, Iaccarino L, Valadi H, Doria A, Gatto M. Measurement-exclusion chromatography mixed with ultrafiltration effectively isolates extracellular vesicles from human blood samples in well being and illness. Int J Mol Sci. 2023;24:34.

    Article 

    Google Scholar
     

  • Jeppesen DK, Hvam ML, Primdahl-Bengtson B, Boysen AT, Whitehead B, Dyrskjøt L, Orntoft TF, Howard KA, Ostenfeld MS. Comparative evaluation of discrete exosome fractions obtained by differential centrifugation. J Extracell Vesicles. 2014;3:25011.

    Article 
    PubMed 

    Google Scholar
     

  • Yang D, Zhang W, Zhang H, Zhang F, Chen L, Ma L, Larcher LM, Chen S, Liu N, Zhao Q, et al. Progress, alternative, and perspective on exosome isolation – efforts for environment friendly exosome-based theranostics. Theranostics. 2020;10:3684–707.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Tran PHL, Wang T, Yin W, Tran TTD, Nguyen TNG, Lee BJ, Duan W. Aspirin-loaded nanoexosomes as most cancers therapeutics. Int J Pharm. 2019;572: 118786.

    Article 
    PubMed 

    Google Scholar
     

  • Paolini L, Zendrini A, Di Noto G, Busatto S, Lottini E, Radeghieri A, Dossi A, Caneschi A, Ricotta D, Bergese P. Residual matrix from completely different separation strategies impacts exosome organic exercise. Sci Rep. 2016;6:23550.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Liu J, Chen Y, Pei F, Zeng C, Yao Y, Liao W, Zhao Z. Extracellular vesicles in liquid biopsies: potential for illness prognosis. Biomed Res Int. 2021;2021:6611244.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Yang J, Gao X, Xing X, Huang H, Tang Q, Ma S, Xu X, Liang C, Li M, Liao L, Tian W. An isolation system to gather top quality and purity extracellular vesicles from serum. Int J Nanomedicine. 2021;16:6681–92.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Bordas M, Genard G, Ohl S, Nessling M, Richter Ok, Roider T, Dietrich S, Maaß KK, Seiffert M. Optimized protocol for isolation of small extracellular vesicles from human and murine lymphoid tissues. Int J Mol Sci. 2020;21:78.

    Article 

    Google Scholar
     

  • Tulkens J, De Wever O, Hendrix A. Analyzing bacterial extracellular vesicles in human physique fluids by orthogonal biophysical separation and biochemical characterization. Nat Protoc. 2020;15:40–67.

    Article 
    PubMed 

    Google Scholar
     

  • Ilahibaks NF, Lei Z, Mol EA, Deshantri AK, Jiang L, Schiffelers RM, Vader P, Sluijter JPG. Biofabrication of cell-derived nanovesicles: a possible different to extracellular vesicles for regenerative medication. Cells. 2019;8:34.

    Article 

    Google Scholar
     

  • Shirejini SZ, Inci F. The Yin and Yang of exosome isolation strategies: typical follow, microfluidics, and business kits. Biotechnol Adv. 2022;54: 107814.

    Article 
    PubMed 

    Google Scholar
     

  • Patel GK, Khan MA, Zubair H, Srivastava SK, Khushman M, Singh S, Singh AP. Comparative evaluation of exosome isolation strategies utilizing tradition supernatant for optimum yield, purity and downstream purposes. Sci Rep. 2019;9:5335.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Li P, Kaslan M, Lee SH, Yao J, Gao Z. Progress in exosome isolation strategies. Theranostics. 2017;7:789–804.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Sidhom Ok, Obi PO, Saleem A. A evaluation of exosomal isolation strategies: is dimension exclusion chromatography the best choice? Int J Mol Sci. 2020;21:34.

    Article 

    Google Scholar
     

  • Vergauwen G, Dhondt B, Van Deun J, De Smedt E, Berx G, Timmerman E, Gevaert Ok, Miinalainen I, Cocquyt V, Braems G, et al. Confounding elements of ultrafiltration and protein evaluation in extracellular vesicle analysis. Sci Rep. 2017;7:2704.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • He L, Zhu D, Wang J, Wu X. A extremely environment friendly methodology for isolating urinary exosomes. Int J Mol Med. 2019;43:83–90.

    PubMed 

    Google Scholar
     

  • Kim JY, Rhim WK, Yoo YI, Kim DS, Ko KW, Heo Y, Park CG, Han DK. Outlined MSC exosome with excessive yield and purity to enhance regenerative exercise. J Tissue Eng. 2021;12:20417314211008624.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Li A, Zhang T, Zheng M, Liu Y, Chen Z. Exosomal proteins as potential markers of tumor prognosis. J Hematol Oncol. 2017;10:175.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kooijmans SA, Aleza CG, Roffler SR, van Solinge WW, Vader P, Schiffelers RM. Show of GPI-anchored anti-EGFR nanobodies on extracellular vesicles promotes tumour cell focusing on. J Extracell Vesicles. 2016;5:31053.

    Article 
    PubMed 

    Google Scholar
     

  • Zarovni N, Corrado A, Guazzi P, Zocco D, Lari E, Radano G, Muhhina J, Fondelli C, Gavrilova J, Chiesi A. Built-in isolation and quantitative evaluation of exosome shuttled proteins and nucleic acids utilizing immunocapture approaches. Strategies. 2015;87:46–58.

    Article 
    PubMed 

    Google Scholar
     

  • Pallares-Rusiñol A, Moura SL, Martí M, Pividori MI. Electrochemical genosensing of overexpressed GAPDH transcripts in breast most cancers exosomes. Anal Chem. 2023;95:2487–95.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Liu WZ, Ma ZJ, Kang XW. Present standing and outlook of advances in exosome isolation. Anal Bioanal Chem. 2022;414:7123–41.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Konoshenko MY, Lekchnov EA, Vlassov AV, Laktionov PP. Isolation of extracellular vesicles: normal methodologies and newest developments. Biomed Res Int. 2018;2018:8545347.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Choi DY, Park JN, Paek SH, Choi SC, Paek SH. Detecting early-stage malignant melanoma utilizing a calcium switch-enriched exosome subpopulation containing tumor markers as a pattern. Biosens Bioelectron. 2022;198: 113828.

    Article 
    PubMed 

    Google Scholar
     

  • Biagiotti S, Abbas F, Montanari M, Barattini C, Rossi L, Magnani M, Papa S, Canonico B. Extracellular vesicles as new gamers in drug supply: a deal with pink blood cells-derived EVs. Pharmaceutics. 2023;15:34.

    Article 

    Google Scholar
     

  • Ryu KJ, Lee JY, Park C, Cho D, Kim SJ. Isolation of small extracellular vesicles from human serum utilizing a mix of ultracentrifugation with polymer-based precipitation. Ann Lab Med. 2020;40:253–8.

    Article 
    PubMed 

    Google Scholar
     

  • Gallart-Palau X, Serra A, Sze SK. Enrichment of extracellular vesicles from tissues of the central nervous system by PROSPR. Mol Neurodegener. 2016;11:41.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Yasui T, Paisrisarn P, Yanagida T, Konakade Y, Nakamura Y, Nagashima Ok, Musa M, Thiodorus IA, Takahashi H, Naganawa T, et al. Molecular profiling of extracellular vesicles through charge-based seize utilizing oxide nanowire microfluidics. Biosens Bioelectron. 2021;194: 113589.

    Article 
    PubMed 

    Google Scholar
     

  • Lin B, Lei Y, Wang J, Zhu L, Wu Y, Zhang H, Wu L, Zhang P, Yang C. Microfluidic-based exosome evaluation for liquid biopsy. Small Strategies. 2021;5: e2001131.

    Article 
    PubMed 

    Google Scholar
     

  • Yang Q, Cheng L, Hu L, Lou D, Zhang T, Li J, Zhu Q, Liu F. An integrative microfluidic machine for isolation and ultrasensitive detection of lung cancer-specific exosomes from affected person urine. Biosens Bioelectron. 2020;163: 112290.

    Article 
    PubMed 

    Google Scholar
     

  • Lo TW, Zhu Z, Purcell E, Watza D, Wang J, Kang YT, Jolly S, Nagrath D, Nagrath S. Microfluidic machine for high-throughput affinity-based isolation of extracellular vesicles. Lab Chip. 2020;20:1762–70.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Yang J, Pan B, Zeng F, He B, Gao Y, Liu X, Track Y. Magnetic colloid antibodies speed up small extracellular vesicles isolation for point-of-care diagnostics. Nano Lett. 2021;21:2001–9.

    Article 
    PubMed 

    Google Scholar
     

  • Chen H, Yamakawa T, Inaba M, Nakano M, Suehiro J. Characterization of extra-cellular vesicle dielectrophoresis and estimation of its electrical properties. Sensors (Basel). 2022;22:34.


    Google Scholar
     

  • Broman A, Lenshof A, Evander M, Happonen L, Ku A, Malmström J, Laurell T. Multinodal acoustic trapping permits excessive capability and excessive throughput enrichment of extracellular vesicles and microparticles in miRNA and MS proteomics research. Anal Chem. 2021;93:3929–37.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Culbertson CT, Mickleburgh TG, Stewart-James SA, Sellens KA, Pressnall M. Micro complete evaluation techniques: basic advances and organic purposes. Anal Chem. 2014;86:95–118.

    Article 
    PubMed 

    Google Scholar
     

  • Wang C, Zhang D, Yang H, Shi L, Li L, Yu C, Wei J, Ding Q. A lightweight-activated magnetic bead technique utilized in spatio-temporal controllable exosomes isolation. Entrance Bioeng Biotechnol. 2022;10:1006374.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Théry C, Witwer KW, Aikawa E, Alcaraz MJ, Anderson JD, Andriantsitohaina R, Antoniou A, Arab T, Archer F, Atkin-Smith GK, et al. Minimal info for research of extracellular vesicles 2018 (MISEV2018): a place assertion of the Worldwide Society for Extracellular Vesicles and replace of the MISEV2014 tips. J Extracell Vesicles. 2018;7:1535750.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Yu Y, Li YT, Jin D, Yang F, Wu D, Xiao MM, Zhang H, Zhang ZY, Zhang GJ. Electrical and label-free quantification of exosomes with a lowered graphene oxide discipline impact transistor biosensor. Anal Chem. 2019;91:10679–86.

    Article 
    PubMed 

    Google Scholar
     

  • Cosenza S, Ruiz M, Toupet Ok, Jorgensen C, Noël D. Mesenchymal stem cells derived exosomes and microparticles defend cartilage and bone from degradation in osteoarthritis. Sci Rep. 2017;7:16214.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wu JY, Li YJ, Hu XB, Huang S, Xiang DX. Preservation of small extracellular vesicles for purposeful evaluation and therapeutic purposes: a comparative analysis of storage situations. Drug Deliv. 2021;28:162–70.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhang Y, Bi J, Huang J, Tang Y, Du S, Li P. Exosome: a evaluation of its classification, isolation strategies, storage, diagnostic and focused remedy purposes. Int J Nanomedicine. 2020;15:6917–34.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Charoenviriyakul C, Takahashi Y, Nishikawa M, Takakura Y. Preservation of exosomes at room temperature utilizing lyophilization. Int J Pharm. 2018;553:1–7.

    Article 
    PubMed 

    Google Scholar
     

  • Kusuma GD, Barabadi M, Tan JL, Morton DAV, Frith JE, Lim R. To guard and to protect: novel preservation methods for extracellular vesicles. Entrance Pharmacol. 2018;9:1199.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Xu M, Yang Q, Solar X, Wang Y. Current developments within the loading and modification of therapeutic exosomes. Entrance Bioeng Biotechnol. 2020;8: 586130.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Pascucci L, Coccè V, Bonomi A, Ami D, Ceccarelli P, Ciusani E, Viganò L, Locatelli A, Sisto F, Doglia SM, et al. Paclitaxel is integrated by mesenchymal stromal cells and launched in exosomes that inhibit in vitro tumor progress: a brand new strategy for drug supply. J Management Launch. 2014;192:262–70.

    Article 
    PubMed 

    Google Scholar
     

  • Bonomi A, Sordi V, Dugnani E, Ceserani V, Dossena M, Coccè V, Cavicchini L, Ciusani E, Bondiolotti G, Piovani G, et al. Gemcitabine-releasing mesenchymal stromal cells inhibit in vitro proliferation of human pancreatic carcinoma cells. Cytotherapy. 2015;17:1687–95.

    Article 
    PubMed 

    Google Scholar
     

  • Toffoli G, Hadla M, Corona G, Caligiuri I, Palazzolo S, Semeraro S, Gamini A, Canzonieri V, Rizzolio F. Exosomal doxorubicin reduces the cardiac toxicity of doxorubicin. Nanomedicine (Lond). 2015;10:2963–71.

    Article 
    PubMed 

    Google Scholar
     

  • Mendt M, Kamerkar S, Sugimoto H, McAndrews KM, Wu CC, Gagea M, Yang S, Blanko EVR, Peng Q, Ma X, et al. Era and testing of clinical-grade exosomes for pancreatic most cancers. JCI Perception. 2018;3:78.

    Article 

    Google Scholar
     

  • Haney MJ, Zhao Y, Jin YS, Li SM, Bago JR, Klyachko NL, Kabanov AV, Batrakova EV. Macrophage-derived extracellular vesicles as drug supply techniques for triple damaging breast most cancers (TNBC) Remedy. J Neuroimmune Pharmacol. 2020;15:487–500.

    Article 
    PubMed 

    Google Scholar
     

  • Sancho-Albero M, Encabo-Berzosa MDM, Beltrán-Visiedo M, Fernández-Messina L, Sebastián V, Sánchez-Madrid F, Arruebo M, Santamaría J, Martín-Duque P. Environment friendly encapsulation of theranostic nanoparticles in cell-derived exosomes: leveraging the exosomal biogenesis pathway to acquire hole gold nanoparticle-hybrids. Nanoscale. 2019;11:18825–36.

    Article 
    PubMed 

    Google Scholar
     

  • Solar H, Zhang T, Gao J. Extracellular vesicles derived from mesenchymal stem cells: a possible biodrug for acute respiratory misery syndrome therapy. BioDrugs. 2022;36:701–15.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Ma X, Liu B, Fan L, Liu Y, Zhao Y, Ren T, Li Y, Li Y. Native and engineered exosomes for inflammatory illness. Nano Res. 2023;16:6991–7006.

    Article 
    PubMed 

    Google Scholar
     

  • Kim MS, Haney MJ, Zhao Y, Yuan D, Deygen I, Klyachko NL, Kabanov AV, Batrakova EV. Engineering macrophage-derived exosomes for focused paclitaxel supply to pulmonary metastases: in vitro and in vivo evaluations. Nanomedicine. 2018;14:195–204.

    Article 
    PubMed 

    Google Scholar
     

  • Liang G, Zhu Y, Ali DJ, Tian T, Xu H, Si Ok, Solar B, Chen B, Xiao Z. Engineered exosomes for focused co-delivery of miR-21 inhibitor and chemotherapeutics to reverse drug resistance in colon most cancers. J Nanobiotechnology. 2020;18:10.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Smyth T, Kullberg M, Malik N, Smith-Jones P, Graner MW, Anchordoquy TJ. Biodistribution and supply effectivity of unmodified tumor-derived exosomes. J Management Launch. 2015;199:145–55.

    Article 
    PubMed 

    Google Scholar
     

  • Kim HY, Kwon S, Um W, Shin S, Kim CH, Park JH, Kim BS. Useful extracellular vesicles for regenerative medication. Small. 2022;18: e2106569.

    Article 
    PubMed 

    Google Scholar
     

  • Choi H, Choi Y, Yim HY, Mirzaaghasi A, Yoo JK, Choi C. Biodistribution of exosomes and engineering methods for focused supply of therapeutic exosomes. Tissue Eng Regen Med. 2021;18:499–511.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Salunkhe S. Floor functionalization of exosomes for target-specific supply and in vivo imaging & monitoring: Methods and significance. J Management Launch. 2020;326:599–614.

    Article 
    PubMed 

    Google Scholar
     

  • Longatti A, Schindler C, Collinson A, Jenkinson L, Matthews C, Fitzpatrick L, Blundy M, Minter R, Vaughan T, Shaw M, Tigue N. Excessive affinity single-chain variable fragments are particular and versatile focusing on motifs for extracellular vesicles. Nanoscale. 2018;10:14230–44.

    Article 
    PubMed 

    Google Scholar
     

  • Wang C, Li N, Li Y, Hou S, Zhang W, Meng Z, Wang S, Jia Q, Tan J, Wang R, Zhang R. Engineering a HEK-293T exosome-based supply platform for environment friendly tumor-targeting chemotherapy/inside irradiation mixture remedy. J Nanobiotechnology. 2022;20:247.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Yoon HY, Lee D, Lim DK, Koo H, Kim Ok. Copper-free click on chemistry: purposes in drug supply, cell monitoring, and tissue engineering. Adv Mater. 2022;34: e2107192.

    Article 
    PubMed 

    Google Scholar
     

  • Tian T, Zhang HX, He CP, Fan S, Zhu YL, Qi C, Huang NP, Xiao ZD, Lu ZH, Tannous BA, Gao J. Floor functionalized exosomes as focused drug supply automobiles for cerebral ischemia remedy. Biomaterials. 2018;150:137–49.

    Article 
    PubMed 

    Google Scholar
     

  • Koh E, Lee EJ, Nam GH, Hong Y, Cho E, Yang Y, Kim IS. Exosome-SIRPα, a CD47 blockade will increase most cancers cell phagocytosis. Biomaterials. 2017;121:121–9.

    Article 
    PubMed 

    Google Scholar
     

  • Takayama Y, Kusamori Ok, Nishikawa M. Click on Chemistry as a Device for Cell Engineering and Drug Supply. Molecules. 2019;24:8.

    Article 

    Google Scholar
     

  • Hong Y, Nam SM, Moon A. Antibody-drug conjugates and bispecific antibodies focusing on cancers: purposes of click on chemistry. Arch Pharm Res. 2023;46:131–48.

    Article 
    PubMed 

    Google Scholar
     

  • Qi H, Liu C, Lengthy L, Ren Y, Zhang S, Chang X, Qian X, Jia H, Zhao J, Solar J, et al. Blood exosomes endowed with magnetic and focusing on properties for most cancers remedy. ACS Nano. 2016;10:3323–33.

    Article 
    PubMed 

    Google Scholar
     

  • Lv Y, Du X, Tang W, Yang Q, Gao F. Exosomes: the position in tumor tolerance and the potential technique for tumor remedy. Pharmaceutics. 2023;15:462.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kooijmans SAA, Fliervoet LAL, van der Meel R, Fens M, Heijnen HFG. PEGylated and focused extracellular vesicles show enhanced cell specificity and circulation time. J Management Launch. 2016;224:77–85.

    Article 
    PubMed 

    Google Scholar
     

  • Gao X, Ran N, Dong X, Zuo B, Yang R, Zhou Q, Moulton HM, Seow Y, Yin H. Anchor peptide captures, targets, and masses exosomes of various origins for diagnostics and remedy. Sci Transl Med. 2018;10:444.

    Article 

    Google Scholar
     

  • Donoso-Quezada J, Ayala-Mar S, González-Valdez J. State-of-the-art exosome loading and functionalization strategies for enhanced therapeutics: a evaluation. Crit Rev Biotechnol. 2020;40:804–20.

    Article 
    PubMed 

    Google Scholar
     

  • Rayamajhi S, Nguyen TDT, Marasini R, Aryal S. Macrophage-derived exosome-mimetic hybrid vesicles for tumor focused drug supply. Acta Biomater. 2019;94:482–94.

    Article 
    PubMed 

    Google Scholar
     

  • Sato YT, Umezaki Ok, Sawada S, Mukai SA, Sasaki Y, Harada N, Shiku H, Akiyoshi Ok. Engineering hybrid exosomes by membrane fusion with liposomes. Sci Rep. 2016;6:21933.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Lee J, Lee H, Goh U, Kim J, Jeong M, Lee J, Park JH. Mobile engineering with membrane fusogenic liposomes to supply functionalized extracellular vesicles. ACS Appl Mater Interfaces. 2016;8:6790–5.

    Article 
    PubMed 

    Google Scholar
     

  • Lv Q, Cheng L, Lu Y, Zhang X, Wang Y, Deng J, Zhou J, Liu B, Liu J. Thermosensitive exosome-liposome hybrid nanoparticle-mediated chemoimmunotherapy for improved therapy of metastatic peritoneal most cancers. Adv Sci (Weinh). 2020;7:2000515.

    Article 
    PubMed 

    Google Scholar
     

  • Lin Y, Wu J, Gu W, Huang Y, Tong Z, Huang L, Tan J. Exosome-liposome hybrid nanoparticles ship CRISPR/Cas9 System in MSCs. Adv Sci (Weinh). 2018;5:1700611.

    Article 
    PubMed 

    Google Scholar
     

  • O’Brien Ok, Ughetto S, Mahjoum S, Nair AV, Breakefield XO. Uptake, performance, and re-release of extracellular vesicle-encapsulated cargo. Cell Rep. 2022;39: 110651.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Mulcahy LA, Pink RC, Carter DR. Routes and mechanisms of extracellular vesicle uptake. J Extracell Vesicles. 2014;3:78.

    Article 

    Google Scholar
     

  • Sinha D, Roy S, Saha P, Chatterjee N, Bishayee A. Traits in analysis on exosomes in most cancers development and anticancer remedy. Cancers (Basel). 2021;13:8.

    Article 

    Google Scholar
     

  • Takahashi Y, Nishikawa M, Shinotsuka H, Matsui Y, Ohara S, Imai T, Takakura Y. Visualization and in vivo monitoring of the exosomes of murine melanoma B16-BL6 cells in mice after intravenous injection. J Biotechnol. 2013;165:77–84.

    Article 
    PubMed 

    Google Scholar
     

  • Yin Y, Han X, Li C, Solar T, Li Ok, Liu X, Liu M. The standing of industrialization and growth of exosomes as a drug supply system: A evaluation. Entrance Pharmacol. 2022;13: 961127.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Miyanishi M, Tada Ok, Koike M, Uchiyama Y, Kitamura T, Nagata S. Identification of Tim4 as a phosphatidylserine receptor. Nature. 2007;450:435–9.

    Article 
    PubMed 

    Google Scholar
     

  • Wang D, Wan Z, Yang Q, Chen J, Liu Y, Lu F, Tang J. Sonodynamical reversion of immunosuppressive microenvironment in prostate most cancers through engineered exosomes. Drug Deliv. 2022;29:702–13.

    Article 
    PubMed 

    Google Scholar
     

  • Das CK, Jena BC, Banerjee I, Das S, Parekh A, Bhutia SK, Mandal M. Exosome as a novel shuttle for supply of therapeutics throughout organic obstacles. Mol Pharm. 2019;16:24–40.

    Article 
    PubMed 

    Google Scholar
     

  • Tolomeo AM, Zuccolotto G, Malvicini R, De Lazzari G, Penna A, Franco C, Caicci F, Magarotto F, Quarta S, Pozzobon M, et al. Biodistribution of intratracheal, intranasal, and intravenous injections of human mesenchymal stromal cell-derived extracellular vesicles in a mouse mannequin for drug supply research. Pharmaceutics. 2023;15:548.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Perets N, Betzer O, Shapira R, Brenstein S, Angel A, Sadan T, Ashery U, Popovtzer R, Offen D. Golden exosomes selectively goal mind pathologies in neurodegenerative and neurodevelopmental issues. Nano Lett. 2019;19:3422–31.

    Article 
    PubMed 

    Google Scholar
     

  • Kalyane D, Raval N, Maheshwari R, Tambe V, Kalia Ok, Tekade RK. Employment of enhanced permeability and retention impact (EPR): Nanoparticle-based precision instruments for focusing on of therapeutic and diagnostic agent in most cancers. Mater Sci Eng C Mater Biol Appl. 2019;98:1252–76.

    Article 
    PubMed 

    Google Scholar
     

  • Nam GH, Choi Y, Kim GB, Kim S, Kim SA, Kim IS. Rising prospects of exosomes for most cancers therapy: from typical remedy to immunotherapy. Adv Mater. 2020;32: e2002440.

    Article 
    PubMed 

    Google Scholar
     

  • Gong C, Zhang X, Shi M, Li F, Wang S, Wang Y, Wang Y, Wei W, Ma G. Tumor exosomes reprogrammed by low pH are environment friendly focusing on automobiles for good drug supply and personalised remedy towards their homologous tumor. Adv Sci (Weinh). 2021;8:2002787.

    Article 
    PubMed 

    Google Scholar
     

  • Yong T, Zhang X, Bie N, Zhang H, Zhang X, Li F, Hakeem A, Hu J, Gan L, Santos HA, Yang X. Tumor exosome-based nanoparticles are environment friendly drug carriers for chemotherapy. Nat Commun. 2019;10:3838.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Yong T, Wang D, Li X, Yan Y, Hu J, Gan L, Yang X. Extracellular vesicles for tumor focusing on supply primarily based on 5 options precept. J Management Launch. 2020;322:555–65.

    Article 
    PubMed 

    Google Scholar
     

  • Kim MS, Haney MJ, Zhao Y, Mahajan V, Deygen I, Klyachko NL, Inskoe E, Piroyan A, Sokolsky M, Okolie O, et al. Improvement of exosome-encapsulated paclitaxel to beat MDR in most cancers cells. Nanomedicine. 2016;12:655–64.

    Article 
    PubMed 

    Google Scholar
     

  • Wei H, Chen J, Wang S, Fu F, Zhu X, Wu C, Liu Z, Zhong G, Lin J. A nanodrug consisting of doxorubicin and exosome derived from mesenchymal stem cells for osteosarcoma therapy in vitro. Int J Nanomedicine. 2019;14:8603–10.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wei H, Chen F, Chen J, Lin H, Wang S, Wang Y, Wu C, Lin J, Zhong G. Mesenchymal stem cell derived exosomes as nanodrug provider of doxorubicin for focused osteosarcoma remedy through SDF1-CXCR4 Axis. Int J Nanomedicine. 2022;17:3483–95.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Bukowski Ok, Kciuk M, Kontek R. Mechanisms of multidrug resistance in most cancers chemotherapy. Int J Mol Sci. 2020;21:34.

    Article 

    Google Scholar
     

  • Walczak H, Miller RE, Ariail Ok, Gliniak B, Griffith TS, Kubin M, Chin W, Jones J, Woodward A, Le T, et al. Tumoricidal exercise of tumor necrosis factor-related apoptosis-inducing ligand in vivo. Nat Med. 1999;5:157–63.

    Article 
    PubMed 

    Google Scholar
     

  • van der Sloot AM, Tur V, Szegezdi E, Mullally MM, Cool RH, Samali A, Serrano L, Quax WJ. Designed tumor necrosis factor-related apoptosis-inducing ligand variants initiating apoptosis completely through the DR5 receptor. Proc Natl Acad Sci U S A. 2006;103:8634–9.

    Article 
    PubMed 

    Google Scholar
     

  • Dianat-Moghadam H, Heidarifard M, Mahari A, Shahgolzari M, Keshavarz M, Nouri M, Amoozgar Z. TRAIL in oncology: from recombinant TRAIL to nano- and self-targeted TRAIL-based therapies. Pharmacol Res. 2020;155: 104716.

    Article 
    PubMed 

    Google Scholar
     

  • Jiang L, Gu Y, Du Y, Tang X, Wu X, Liu J. Engineering exosomes endowed with focused supply of triptolide for malignant melanoma remedy. ACS Appl Mater Interfaces. 2021;13:42411–28.

    Article 
    PubMed 

    Google Scholar
     

  • Qiu Y, Solar J, Qiu J, Chen G, Wang X, Mu Y, Li Ok, Wang W. Antitumor Exercise of Cabazitaxel and MSC-TRAIL derived extracellular vesicles in drug-resistant oral squamous cell carcinoma. Most cancers Manag Res. 2020;12:10809–20.

    Article 
    PubMed 

    Google Scholar
     

  • Yuan Q, Su Ok, Li S, Lengthy X, Liu L, Yang M, Yuan X, Solar J, Hu J, Li Q, et al. Pulmonary supply of extracellular vesicle-encapsulated dinaciclib as an efficient lung most cancers remedy. Cancers (Basel). 2022;14:89.

    Article 

    Google Scholar
     

  • Gu Y, Du Y, Jiang L, Tang X, Li A, Zhao Y, Lang Y, Liu X, Liu J. αvβ3 integrin-specific exosomes engineered with cyclopeptide for focused supply of triptolide towards malignant melanoma. J Nanobiotechnology. 2022;20:384.

    Article 
    PubMed 

    Google Scholar
     

  • Gong C, Tian J, Wang Z, Gao Y, Wu X, Ding X, Qiang L, Li G, Han Z, Yuan Y, Gao S. Useful exosome-mediated co-delivery of doxorubicin and hydrophobically modified microRNA 159 for triple-negative breast most cancers remedy. J Nanobiotechnology. 2019;17:93.

    Article 
    PubMed 

    Google Scholar
     

  • Mita AC, Mita MM, Nawrocki ST, Giles FJ. Survivin: key regulator of mitosis and apoptosis and novel goal for most cancers therapeutics. Clin Most cancers Res. 2008;14:5000–5.

    Article 
    PubMed 

    Google Scholar
     

  • Zhang X, Males Ok, Zhang Y, Zhang R, Yang L, Duan X. Native and systemic supply of mRNA encoding survivin-T34A by lipoplex for environment friendly colon most cancers gene remedy. Int J Nanomedicine. 2019;14:2733–51.

    Article 
    PubMed 

    Google Scholar
     

  • Aspe JR, Diaz Osterman CJ, Jutzy JM, Deshields S, Whang S, Wall NR. Enhancement of Gemcitabine sensitivity in pancreatic adenocarcinoma by novel exosome-mediated supply of the Survivin-T34A mutant. J Extracell Vesicles. 2014;3:23.

    Article 

    Google Scholar
     

  • Yim N, Ryu SW, Choi Ok, Lee KR, Lee S, Choi H, Kim J, Shaker MR, Solar W, Park JH, et al. Exosome engineering for environment friendly intracellular supply of soluble proteins utilizing optically reversible protein-protein interplay module. Nat Commun. 2016;7:12277.

    Article 
    PubMed 

    Google Scholar
     

  • Nordmeier S, Ke W, Afonin KA, Portnoy V. Exosome mediated supply of purposeful nucleic acid nanoparticles (NANPs). Nanomedicine. 2020;30: 102285.

    Article 
    PubMed 

    Google Scholar
     

  • Zhang Y, Liu Q, Zhang X, Huang H, Tang S, Chai Y, Xu Z, Li M, Chen X, Liu J, Yang C. Current advances in exosome-mediated nucleic acid supply for most cancers remedy. J Nanobiotechnology. 2022;20:279.

    Article 
    PubMed 

    Google Scholar
     

  • Kamerkar S, Burzyn D, Leng C, Burenkova O, Jang SC, Yang R, Boutin A, Kirwin Ok, Zi T, Dahlberg W, et al. Summary A50: Reprogramming of tumor-associated M2 macrophages with antisense oligonucleotide-loaded exosomes leads to potent single-agent antitumor exercise. Most cancers Immunol Res. 2020;8:A50–A50.

    Article 

    Google Scholar
     

  • Wilbie D, Walther J, Mastrobattista E. Supply facets of CRISPR/Cas for in vivo genome enhancing. Acc Chem Res. 2019;52:1555–64.

    Article 
    PubMed 

    Google Scholar
     

  • McAndrews KM, Xiao F, Chronopoulos A, LeBleu VS, Kugeratski FG, Kalluri R. Exosome-mediated supply of CRISPR/Cas9 for focusing on of oncogenic Kras(G12D) in pancreatic most cancers. Life Sci Alliance. 2021;4:875.

    Article 

    Google Scholar
     

  • Wang JK, Wang Z, Li G. MicroRNA-125 in immunity and most cancers. Most cancers Lett. 2019;454:134–45.

    Article 
    PubMed 

    Google Scholar
     

  • Wang X, Zhang H, Bai M, Ning T, Ge S, Deng T, Liu R, Zhang L, Ying G, Ba Y. Exosomes function nanoparticles to ship anti-miR-214 to reverse chemoresistance to cisplatin in gastric most cancers. Mol Ther. 2018;26:774–83.

    Article 
    PubMed 

    Google Scholar
     

  • Yan Y, Du C, Duan X, Yao X, Wan J, Jiang Z, Qin Z, Li W, Pan L, Gu Z, et al. Inhibiting collagen I manufacturing and tumor cell colonization within the lung through miR-29a-3p loading of exosome-/liposome-based nanovesicles. Acta Pharm Sin B. 2022;12:939–51.

    Article 
    PubMed 

    Google Scholar
     

  • Kirave P, Gondaliya P, Kulkarni B, Rawal R, Garg R, Jain A, Kalia Ok. Exosome mediated miR-155 supply confers cisplatin chemoresistance in oral most cancers cells through epithelial-mesenchymal transition. Oncotarget. 2020;11:1157–71.

    Article 
    PubMed 

    Google Scholar
     

  • Castanotto D, Rossi JJ. The guarantees and pitfalls of RNA-interference-based therapeutics. Nature. 2009;457:426–33.

    Article 
    PubMed 

    Google Scholar
     

  • Tatiparti Ok, Sau S, Kashaw SK, Iyer AK. siRNA Supply Methods: A Complete Assessment of Current Developments. Nanomaterials (Basel). 2017;7:89.

    Article 

    Google Scholar
     

  • Lin D, Zhang H, Liu R, Deng T, Ning T, Bai M, Yang Y, Zhu Ok, Wang J, Duan J, et al. iRGD-modified exosomes successfully ship CPT1A siRNA to colon most cancers cells, reversing oxaliplatin resistance by regulating fatty acid oxidation. Mol Oncol. 2021;15:3430–46.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Xia J, Miao Y, Wang X, Huang X, Dai J. Current progress of dendritic cell-derived exosomes (Dex) as an anti-cancer nanovaccine. Biomed Pharmacother. 2022;152: 113250.

    Article 
    PubMed 

    Google Scholar
     

  • Kugeratski FG, Kalluri R. Exosomes as mediators of immune regulation and immunotherapy in most cancers. Febs j. 2021;288:10–35.

    Article 
    PubMed 

    Google Scholar
     

  • Xiao Q, Li X, Li Y, Wu Z, Xu C, Chen Z, He W. Organic drug and drug delivery-mediated immunotherapy. Acta Pharm Sin B. 2021;11:941–60.

    Article 
    PubMed 

    Google Scholar
     

  • Zhang H, Wang S, Solar M, Cui Y, Xing J, Teng L, Xi Z, Yang Z. Exosomes as good drug supply automobiles for most cancers immunotherapy. Entrance Immunol. 2022;13:1093607.

    Article 
    PubMed 

    Google Scholar
     

  • Fu C, Zhou L, Mi QS, Jiang A. Plasmacytoid dendritic cells and most cancers immunotherapy. Cells. 2022;11:67.

    Article 

    Google Scholar
     

  • Wang R, Xu A, Zhang X, Wu J, Freywald A, Xu J, Xiang J. Novel exosome-targeted T-cell-based vaccine counteracts T-cell anergy and converts CTL exhaustion in persistent an infection through CD40L signaling by the mTORC1 pathway. Cell Mol Immunol. 2017;14:529–45.

    Article 
    PubMed 

    Google Scholar
     

  • Lee EY, Park KS, Yoon YJ, Lee J, Moon HG, Jang SC, Choi KH, Kim YK, Gho YS. Therapeutic results of autologous tumor-derived nanovesicles on melanoma progress and metastasis. PLoS ONE. 2012;7:e33330.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Fu C, Zhou L, Mi QS, Jiang A. DC-Based mostly Vaccines for Most cancers Immunotherapy. Vaccines (Basel). 2020;8:78.


    Google Scholar
     

  • Stefanius Ok, Servage Ok, de Souza SM, Grey HF, Toombs JE, Chimalapati S, Kim MS, Malladi VS, Brekken R, Orth Ok. Human pancreatic most cancers cell exosomes, however not human regular cell exosomes, act as an initiator in cell transformation. Elife. 2019;8:345.

    Article 

    Google Scholar
     

  • Capello M, Vykoukal JV, Katayama H, Bantis LE, Wang H, Kundnani DL, Aguilar-Bonavides C, Aguilar M, Tripathi SC, Dhillon DS, et al. Exosomes harbor B cell targets in pancreatic adenocarcinoma and exert decoy perform towards complement-mediated cytotoxicity. Nat Commun. 2019;10:254.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Pagotto S, Simeone P, Brocco D, Catitti G, De Bellis D, Vespa S, Di Pietro N, Marinelli L, Di Stefano A, Veschi S, et al. CAR-T-derived extracellular vesicles: a promising growth of CAR-T anti-tumor remedy. Cancers (Basel). 2023;15:4.

    Article 

    Google Scholar
     

  • Schubert ML, Schmitt M, Wang L, Ramos CA, Jordan Ok, Müller-Tidow C, Dreger P. Facet-effect administration of chimeric antigen receptor (CAR) T-cell remedy. Ann Oncol. 2021;32:34–48.

    Article 
    PubMed 

    Google Scholar
     

  • Hernani R, Benzaquén A, Solano C. Toxicities following CAR-T remedy for hematological malignancies. Most cancers Deal with Rev. 2022;111: 102479.

    Article 
    PubMed 

    Google Scholar
     

  • Fu W, Lei C, Liu S, Cui Y, Wang C, Qian Ok, Li T, Shen Y, Fan X, Lin F, et al. CAR exosomes derived from effector CAR-T cells have potent antitumour results and low toxicity. Nat Commun. 2019;10:4355.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Shi Y, Zhang J, Mao Z, Jiang H, Liu W, Shi H, Ji R, Xu W, Qian H, Zhang X. Extracellular vesicles from gastric most cancers cells induce PD-L1 expression on neutrophils to suppress T-cell immunity. Entrance Oncol. 2020;10:629.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zocchi MR, Tosetti F, Benelli R, Poggi A. Most cancers Nanomedicine Particular Difficulty Assessment Anticancer Drug Supply with Nanoparticles: Extracellular Vesicles or Artificial Nanobeads as Therapeutic Instruments for Typical Remedy or Immunotherapy. Cancers Basel 2020; 12:34

  • Fan Y, Zhou Y, Lu M, Si H, Li L, Tang B. Responsive dual-targeting exosome as a drug provider for mixture most cancers immunotherapy. Analysis (Wash D C). 2021;2021:9862876.

    PubMed 

    Google Scholar
     

  • Wang D, Wang C, Wang L, Chen Y. A complete evaluation in bettering supply of small-molecule chemotherapeutic brokers overcoming the blood-brain/mind tumor obstacles for glioblastoma therapy. Drug Deliv. 2019;26:551–65.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Conti A, Geffroy F, Kamimura HAS, Novell A, Tournier N, Mériaux S, Larrat B. Regulation of P-glycoprotein and breast most cancers resistance protein expression induced by centered ultrasound-mediated blood-brain barrier disruption: a pilot examine. Int J Mol Sci. 2022;23:34.

    Article 

    Google Scholar
     

  • van Tellingen O, Yetkin-Arik B, de Gooijer MC, Wesseling P, Wurdinger T, de Vries HE. Overcoming the blood-brain tumor barrier for efficient glioblastoma therapy. Drug Resist Updat. 2015;19:1–12.

    Article 
    PubMed 

    Google Scholar
     

  • Xu M, Feng T, Liu B, Qiu F, Xu Y, Zhao Y, Zheng Y. Engineered exosomes: fascinating target-tracking traits for cerebrovascular and neurodegenerative illness therapies. Theranostics. 2021;11:8926–44.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Deng Z, Wang J, Xiao Y, Li F, Niu L, Liu X, Meng L, Zheng H. Ultrasound-mediated augmented exosome launch from astrocytes alleviates amyloid-β-induced neurotoxicity. Theranostics. 2021;11:4351–62.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Yang T, Martin P, Fogarty B, Brown A, Schurman Ok, Phipps R, Yin VP, Lockman P, Bai S. Exosome delivered anticancer medicine throughout the blood-brain barrier for mind most cancers remedy in Danio rerio. Pharm Res. 2015;32:2003–14.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Yang T, Fogarty B, LaForge B, Aziz S, Pham T, Lai L, Bai S. Supply of small interfering RNA to inhibit vascular endothelial progress think about zebrafish utilizing pure mind endothelia cell-secreted exosome nanovesicles for the therapy of mind most cancers. Aaps j. 2017;19:475–86.

    Article 
    PubMed 

    Google Scholar
     

  • Liang SF, Zuo FF, Yin BC, Ye BC. Supply of siRNA primarily based on engineered exosomes for glioblastoma remedy by focusing on STAT3. Biomater Sci. 2022;10:1582–90.

    Article 
    PubMed 

    Google Scholar
     

  • Reale A, Khong T, Spencer A. Extracellular vesicles and their roles within the tumor immune microenvironment. J Clin Med. 2022;11:23.

    Article 

    Google Scholar
     

  • Mantovani A, Allavena P, Marchesi F, Garlanda C. Macrophages as instruments and targets in most cancers remedy. Nat Rev Drug Discov. 2022;21:799–820.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Murray PJ. Macrophage polarization. Annu Rev Physiol. 2017;79:541–66.

    Article 
    PubMed 

    Google Scholar
     

  • Kamerkar S, Leng C, Burenkova O, Jang SC, McCoy C, Zhang Ok, Dooley Ok, Kasera S, Zi T, Sisó S, et al. Exosome-mediated genetic reprogramming of tumor-associated macrophages by exoASO-STAT6 results in potent monotherapy antitumor exercise. Sci Adv. 2022;8:eabj7002.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhu D, Liu Z, Li Y, Huang Q, Xia L, Li Ok. Supply of manganese carbonyl to the tumor microenvironment utilizing Tumor-Derived exosomes for most cancers fuel remedy and low dose radiotherapy. Biomaterials. 2021;274: 120894.

    Article 
    PubMed 

    Google Scholar
     

  • Zhang M, Hu S, Liu L, Dang P, Liu Y, Solar Z, Qiao B, Wang C. Engineered exosomes from completely different sources for cancer-targeted remedy. Sign Transduct Goal Ther. 2023;8:124.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Gomes ER, Carvalho AT, Barbosa TC, Ferreira LL, Calado HDR, Sabino AP, Oliveira MC. Fusion of tumor-derived exosomes with long-circulating and pH-sensitive liposomes loaded with doxorubicin for the therapy of breast most cancers. AAPS PharmSciTech. 2022;23:255.

    Article 
    PubMed 

    Google Scholar
     

  • Gomes ER, Souza FR, Cassali GD, Sabino AP, Barros ALB, Oliveira MC. Investigation of the antitumor exercise and toxicity of tumor-derived exosomes fused with long-circulating and pH-sensitive liposomes containing doxorubicin. Pharmaceutics. 2022;14:3.

    Article 

    Google Scholar
     

  • Alix-Panabières C, Pantel Ok. Liquid biopsy: from discovery to medical software. Most cancers Discov. 2021;11:858–73.

    Article 
    PubMed 

    Google Scholar
     

  • Marrugo-Ramírez J, Mir M, Samitier J. Blood-based most cancers biomarkers in liquid biopsy: a promising non-invasive different to tissue biopsy. Int J Mol Sci. 2018;19:34.

    Article 

    Google Scholar
     

  • Li Ok, Lin Y, Luo Y, Xiong X, Wang L, Durante Ok, Li J, Zhou F, Guo Y, Chen S, et al. A signature of saliva-derived exosomal small RNAs as predicting biomarker for esophageal carcinoma: a multicenter potential examine. Mol Most cancers. 2022;21:21.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Nakano T, Chen IH, Wang CC, Chen PJ, Tseng HP, Huang KT, Hu TH, Li LC, Goto S, Cheng YF, et al. Circulating exosomal miR-92b: Its position for most cancers immunoediting and medical worth for prediction of posttransplant hepatocellular carcinoma recurrence. Am J Transplant. 2019;19:3250–62.

    Article 
    PubMed 

    Google Scholar
     

  • Aboulkheyr Es H, Montazeri L, Aref AR, Vosough M, Baharvand H. Personalised most cancers medication: an organoid strategy. Traits Biotechnol. 2018;36:358–71.

    Article 
    PubMed 

    Google Scholar
     

  • Richards T, Patel H, Patel Ok, Schanne F. Endogenous lipid carriers-bench-to-bedside roadblocks in manufacturing and drug loading of exosomes. Prescription drugs (Basel). 2023;16:421.

    Article 
    PubMed 

    Google Scholar
     

  • Emam SE, Ando H, Abu Lila AS, Shimizu T, Ukawa M, Okuhira Ok, Ishima Y, Mahdy MA, Ghazy FS, Ishida T. A novel technique to extend the yield of exosomes (extracellular vesicles) for an growth of primary analysis. Biol Pharm Bull. 2018;41:733–42.

    Article 
    PubMed 

    Google Scholar
     

  • Busatto S, Vilanilam G, Ticer T, Lin WL, Dickson DW, Shapiro S, Bergese P, Wolfram J. Tangential movement filtration for extremely environment friendly focus of extracellular vesicles from giant volumes of fluid. Cells. 2018;7:23.

    Article 

    Google Scholar
     

  • Gandham S, Su X, Wooden J, Nocera AL, Alli SC, Milane L, Zimmerman A, Amiji M, Ivanov AR. Applied sciences and standardization in analysis on extracellular vesicles. Traits Biotechnol. 2020;38:1066–98.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Li D, Gong L, Lin H, Yao S, Yin Y, Zhou Z, Shi J, Wu Z, Huang Z. Hyaluronic acid-coated bovine milk exosomes for reaching tumor-specific intracellular supply of miRNA-204. Cells. 2022;11:12.


    Google Scholar
     

  • Ren C, Li Y, Cong Z, Li Z, Xie L, Wu S. Bioengineered bacterial outer membrane vesicles encapsulated Polybia-mastoparan I fusion peptide as a promising nanoplatform for bladder most cancers immune-modulatory chemotherapy. Entrance Immunol. 2023;14:1129771.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Xu Z, Xu Y, Zhang Ok, Liu Y, Liang Q, Thakur A, Liu W, Yan Y. Plant-derived extracellular vesicles (PDEVs) in nanomedicine for human illness and therapeutic modalities. J Nanobiotechnology. 2023;21:114.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kong L, Yang C, Zhang Z. Organism-generated organic vesicles in situ: an rising drug supply technique. Adv Sci (Weinh). 2023;10: e2204178.

    Article 
    PubMed 

    Google Scholar
     

  • Hussen BM, Faraj GSH, Rasul MF, Hidayat HJ, Salihi A, Baniahmad A, Taheri M, Ghafouri-Frad S. Methods to beat the primary challenges of using exosomes as drug provider for most cancers remedy. Most cancers Cell Int. 2022;22:323.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

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